In today's gamer age I feel that Make Human should support the Unreal Engine, and Unity rigs. (I've used both but prefer UE4.) This would make character creation a breeze and allow instant game compatibility so users can dive right in. I know UE4 has a custom rig, but I'm certain you can figure it out. it would be so awesome to make the character then, add clothes (or make my own within Blender/Mavelous designer and import them) and have a game ready character who instantly uses all the animations of the engine without having to retarget and fix the root bones.
As for the anime, since Manuel Bastoni Lab went down, you should also include at least the realistic anime, which seems the most compatible of the anime series. Of course I don't know about under the hood but it would be sweet to have my custom character within MH, or at least allow an import that rigs it the same as a MH character.
Anyhow, that's my thoughts. Thanks for reading and have a fantastic day.
~~InsaneXade