As I'm planning to open another user contrib repo for proxies/topologies, I've amused myself with making a very low poly (408 faces) proxy to see if it's possible to make it deform properly and fit existing skins to it.
Works surprisingly well:
Ok, obviously the skin doesn't look entirely convincing in this setting, although I think this is in part due to my crappy UV unwrap. However, I doubt anyone who wants a 408 face toon will use a 4096x4096 skin texture for it anyway.